Estimated cut-off values for pemphigus severity classification according to pemphigus disease area index (PDAI), autoimmune bullous skin disorder intensity score (ABSIS), and anti-desmoglein 1 autoantibodies
نویسندگان
چکیده
منابع مشابه
Clinical significance of anti-desmoglein-1 and -3 circulating autoantibodies in Pemphigus Patients Measured by Area Index and Intensity Score.
Detection of anti-desmoglein-1 (anti-DSG-1) and anti-DSG-3 autoantibodies is widely used in the diagnosis of pemphigus. Two validated scoring systems, Pemphigus Disease Area Index (PDAI) and Autoimmune Bullous Skin Disorder Intensity Score (ABSIS), are used for the evaluation of clinical severity. The aim of this cross-sectional study was to interpret the titres of pemphigus autoantibodies in c...
متن کاملIntroducing a novel Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) in pemphigus.
At present, there is no consensus about the clinical criteria that define disease severity of pemphigus. During recent years several scoring systems have been introduced which mainly compare inter-individual differences in disease activity. It thus remains a challenge to reflect the disease activity of individual patients by a standardised scoring system. Due to the remarkable clinical variabil...
متن کاملValidation studies of outcome measures in pemphigus☆☆☆★
Pemphigus is a group of rare and potentially fatal autoimmune blistering diseases that are associated with auto-antibodies that target intercellular adhesion molecules. Incidence of pemphigus varies among populations, with the lowest incidence in Switzerland and Finland at 0.6-0.76 per million per year and the highest in Jewish communities at 16.1-32 per million per year. Pemphigus is associate...
متن کاملDevelopment of an Excel® spreadsheet to document disease activity in autoimmune bullous disease.
Objective measures of disease activity have attracted considerable interest within dermatology because of their capacity to evaluate disease severity through a validated means, to monitor the trajectory of a patient’s disease and as standardised outcome measures in clinical trials (1). Two disease-specific instruments exist for measuring the extent of autoimmune bullous diseases: the Autoimmune...
متن کاملDesmoglein ELISA in the diagnosis of pemphigus and its correlation with the severity of pemphigus vulgaris.
Anti-desmoglein 3 and 1 autoantibodies are involved in the pathogenesis of pemphigus diseases. Our objective was to assess the value of ELISA in the diagnosis of pemphigus and its correlation with the severity of pemphigus vulgaris. Based on clinical presentation and histopathologic confirmation for the diagnosis of the pemphigus, 38 patients took part in the study. Sera of the patients were te...
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ژورنال
عنوان ژورنال: BMC Dermatology
سال: 2020
ISSN: 1471-5945
DOI: 10.1186/s12895-020-00105-y